gene replacement

A Primary Study of an Antifreeze Gene Expressed Highly in E. coli and Yeast through Base Replacement

鱼抗冻蛋白在E.coli和Yeast中高效表达的理论初探

An A was replaced by a G in codon 38 upstream of the 5 ′ border outside the HMG box of the SRY gene, resulting in the replacement of the amino acid glutamate by glycine.

一个突变发生在SRY基因的5′端HMG盒外的核苷酸第113位腺嘌呤（A）被鸟嘌呤（G）取代，并导致谷氨酸被甘氨酸替换；

DNA repair approach has focused on gene targeting or gene replacement whereby the defective gene is removed and a normal gene is inserted at the same position in the chromosome and so it maintains the corrected gene's expression in the natural context.

基因原位修复策略是一种直接的基因疗法，它针对基因缺陷部位进行修复，保持了基因原有的染色质环境，因此是一种理想的靶向性基因治疗方式。